Interaction between microvascular alpha 1- and alpha 2-adrenoceptors and endothelium-derived relaxing factor.
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چکیده
منابع مشابه
Interaction Between Microvascular a 1 - and a 2 - Adrenoceptors and Endothelium - Derived Relaxing Factor
Intravital microscopy was used to study the effect of endothelium-derived relaxing factor (EDRF) on microvascular adrenoceptor sensitivity in rat cremaster skeletal muscle. NG-Monomethyl L-arginine (L-NMMA, 1-300 ,uM), an inhibitor ofEDRF formation, produced concentration-dependent constriction of arterioles and venules. When an intermediate amount of a-l versus a2-adrenoceptor tone was first p...
متن کاملInteraction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins.
Endothelin-1 is a 21-amino acid endothelial vasoconstrictor peptide that may be the physiological antagonist of endothelium-derived relaxing factor (EDRF). Endothelin-1 (10(-11)-3 x 10(-7) M) evoked potent contractions of isolated internal mammary arteries, internal mammary veins, and saphenous veins, which were enhanced in internal mammary veins as compared with internal mammary arteries (conc...
متن کاملEndothelium-Derived Relaxing Factor
The vascular effects of endothelin-1 (ET) in humans were investigated by brachial artery infusions of ET into 25 healthy volunteers. Forearm blood flow increased from a mean±SD value of 2.3± 1.5 to 2.5± 1.5 ml/min/100 ml forearm tissue (n=25, p<0.05) in response to low dose (0.5 ng/min/100 ml forearm tissue) ET infusion and decreased to 1.78±1.3 and 1.1±0.9 ml/min/100 ml forearm tissue (p<0.001...
متن کاملFaber , D R Gettes and D P Gianturco 2 - adrenoceptors . Microvascular effects of atrial natriuretic factor : interaction with alpha 1 - and alpha
2-adrenoceptors. Microvascular effects of atrial natriuretic factor: interaction with alpha 1and alpha Print ISSN: 0009-7330. Online ISSN: 1524-4571 Copyright © 1988 American Heart Association, Inc. All rights reserved. is published by the American Heart Association, 7272 Greenville Avenue, Dallas, TX 75231 Circulation Research doi: 10.1161/01.RES.63.2.415 1988;63:415-428 Circ Res. http://circr...
متن کاملEndothelium-derived vascular relaxing factor.
A large number and variety of compounds (acetylcholine, adenosine diphosphate, adenosine triphosphate, arachidonic acid, bradykinin, Ca2+ ionophores, calcitonin gene-related peptide, histamine, hydralazine, substance P, thrombin, and vasoactive intestinal polypeptide) have been shown to relax arterial smooth muscle indirectly. The endothelium in muscular arteries from several species appears to...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 1992
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.71.1.188